Our mission is to help patients who have heart failure by bridging the scientific gaps between molecular, cellular and organ-level function.

If you are a patient, or you care about somebody who has heart disease, you can learn more about heart failure at Heart Failure 101.

We have three main goals. 
  1. Identify the molecular changes that have the biggest impact on the heart's ability to pump blood. These can be targeted with new therapies to rescue cardiac function.

  2. Understand the relationship between torsion (twisting of the heart) and transmural variation (changes in cellular properties across the ventricular wall). This will help to explain the underlying problem in patients who have cardiac disease.

  3. Integrate cardiac imaging and computer modeling to predict how therapies will affect function. This will help clinicians to develop patient-specific treatment plans.
We use biophysical, biochemical, and computational techniques and we collaborate extensively with cardiothoracic surgeons and cardiologists. Many of our experiments use tissue samples isolated from patients undergoing heart transplants and other cardiac surgeries. Our cardiac biobank now contains ~2800 samples from more than 180 patients and organ donors.

We are part of the Department of Physiology in the College of Medicine and members of the Center for Muscle Biology

Please contact us if you have questions or you want to visit the lab. We are delighted to show you around and explain what we do in more detail.


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