Cardiac samples‎ > ‎

Information for collaborators

Last updated 17 Feb, 2017

Overview

Working in collaboration with the University of Kentucky Center for Transplant and Organ Failure and the Gill Heart Institute, the Campbell lab manages a collection of cardiac tissue isolated from organ donors and patients undergoing surgeries.

Since 2008, we have procured ~5000 samples from different regions of ~250 human hearts. Most of the samples are flash-frozen and subsequently stored in the vapor phase of liquid nitrogen but we have also performed experiments using living myocytes and electrically isolated trabecualae. All of the samples are linked to medical records.

The program has received financial support from the University of Kentucky Center for Muscle Biology, the University of Kentucky Center for Clinical and Translational Science, and the American Heart Association (Grant-in-Aid). The PIs of the program have been Mark Bonnell, MD (Surgery, 2008-2010), Chuck Hoopes, MD (Surgery, 2010 to 2014), Maya Guglin, MD (Cardiology, 2014 to present).

When possible, the Campbell lab wants to use these valuable samples to help support collaborations with other research labs. However, we want to do this without draining our limited resources and/or detracting from research programs at the University of Kentucky. This page describes some general (non-binding) guidelines that will help us to achieve these goals.

If you have questions, please email biobank@campbellmusclelab.org.

Collaborations

Our IRB protocol allows us to share samples acquire after November 2013 with collaborators at other institutions. This accelerates research that will help patients by allowing scientists at other institutions to perform experiments that we would not be able to complete by ourselves.

Before we can distribute samples to a new investigator, we need
  1. A completed Material Transfer Agreement between the University of Kentucky and the new institution

  2. Documentation from the IRB or equivalent organization at the host institution showing that the scientists have permission to use our samples.

    Since we will only provide samples and clinical data that are deidentified, most IRBs in the USA rule that the research is exempt (that is, it does not involve experiments with samples that can be linked to specific people.) The documentation can often be arranged with a phone call or an email to the institutional research office.
If you would like to collaborate with us, please email biobank@campbellmusclelab.org.

Medical data

Our IRB allows us to share deidentified medical data relating to the patients and/or organ donors. This is extracted from the medical records (in the case of patients) and UNOS records (in the case of organ donors). We do not have complete data about every sample.

Costs

Collaborators are expected to pay for shipping and handling and any other reasonable costs associated with sample preparation.

Grant applications

Collaborators who wish to acquire samples on an ongoing basis are expected to build relevant costs into their grant applications. This will help the Campbell lab to maintain and build the resource.

Please email biobank@campbellmusclelab.org to discuss options and to arrange for supporting documentation.


Authorship

The Campbell lab recommends the following procedures for authorship.
  • Campbell lab members who contribute intellectually to the experimental design by, for example, selecting samples that match certain clinical criteria and/or helping with data interpretation, should be considered for authorship.

  • Campbell lab members who collected tissue samples that are used in the published experiments and/or coordinated sample distribution will be acknowledged.

  • Campbell lab members who collated data from the medical records that are included in the publication will be acknowledged.
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