We have three main goals. 
  1. Identify the molecular changes that have the biggest impact on the heart's ability to pump blood. These can be targeted with new therapies to rescue cardiac function.

  2. Understand the relationship between torsion (twisting of the heart) and transmural variation (changes in cellular properties across the ventricular wall). This will help to explain the underlying problem in patients who have cardiac disease.

  3. Integrate cardiac imaging and computer modeling to predict how therapies will affect function. This will help clinicians to develop patient-specific treatment plans.

More information about specific projects