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Heart failure

As described in our Heart failure 101 page, a person has heart failure when they cannot pump enough blood to meet their basal demands.

There are lots of ways of categorizing heart failure but a common approach is to distinguish between hearts that don't fill properly (called Heart Failure with preserved Ejection Fraction, HFpEF) and hearts that don't eject adequately (Heart Failure with reduced Ejection Fraction, HFrEF).

We are trying to discover molecular-level mechanisms that contribute to these diseases. We hope that this will help scientists and researchers to develop better therapies for heart failure.

You can read more about some of our particular interests by the following the links below.

Heart failure with preserved ejection fraction

Transmural variation in contractile function
Contraction kinetics